RESEARCH ARTICLE


The Influence of Lactobacillus Acidophilus on MUC1, GAL-3, IL-1β and IL-17 Gene Expression in BALB/c Mice Stomach



Fanny Rahardja1, *, Dwi Prasetyo2, Muhammad N. Shahib3, Susy Tjahjani4
1 Department of Microbiology, Faculty of Medicine, Maranatha Christian University, Bandung, Indonesia
2 Department of Child Health of Faculty of Medicine, Universitas Padjadjaran, Bandung, Indonesia
3 Department of Biochemistry and Molecular Biology, Faculty of Medicine, Universitas Padjadjaran, Bandung, Indonesia
4 Department of Parasitology, Faculty of Medicine, Maranatha Christian University, Bandung, Indonesia


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Creative Commons License
© 2021 Rahardja et al.

open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: https://creativecommons.org/licenses/by/4.0/legalcode. This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

* Address correspondence to this author at Department of Microbiology, Faculty of Medicine, Maranatha Christian University, Bandung, Indonesia; Tel: +62222012186; E-mail: fanny.rahardja19@gmail.com


Abstract

Background and Objective:

Lactobacillus acidophilus has been widely used for the management of gastrointestinal carcinoma owing to its immunomodulation effect; however, the role of L. acidophilus and its specific mechanism of action in the stomach is not fully comprehended. The present study evaluated the expression profile of MUC-1, GAL-3, IL -1β, and IL-17 in the L. acidophilus treated mice stomach.

Methods:

The study was conducted utilizing three groups of mice, 6 mice for each group, administered with different doses of L. acidophilus and a control group treated with normal saline. The results were analyzed with the Mann-Whitney Test.

Results:

The results demonstrated that L. acidophilus elevated IL-1β insignificantly and inhibited the expression of IL-17. The MUC-1 expression is influenced by L. acidophilus and inversely proportional to GAL-3 expression.

Conclusion:

Lactobacillus acidophilus plays a prominent role against inflammatory responses and has a potential in the treatment of gastrointestinal cancer.

Keywords: Lactobacillus acidophilus, Gastrointestinal carcinoma, Immunomodulation, Muc-1, Gal-3, IL-1β, IL-17.