Live Attenuated Reassortant Vaccines Based on A/Leningrad/134/17/57 Master Donor Virus Against H5 Avian Influenza

Irina Kiseleva1, 2, *, Natalie Larionova1, Larisa Rudenko1
1 Institute of Experimental Medicine; St Petersburg, Russia
2 Saint Petersburg State University, St Petersburg, Russia

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© 2017 Kiseleva et al.

open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

* Address correspondence to this author at the Institute of Experimental Medicine, 12 Acad. Pavlov Street, 197376, St. Petersburg, Russia; Tel: +7(812)2346860l; E-mail:



The H5N1 avian influenza was first recognized in humans in Hong Kong 20 years ago. Current enzootic spread of highly pathogenic H5N1 virus among wild and domestic poultry and a number of severe human respiratory diseases caused by this pathogen have stimulated necessity of development of potentially pandemic influenza vaccines.


In the past few years, significant research was conducted on how to prevent H5N1 influenza. Live, attenuated cold–adapted reassortant influenza vaccine (LAIV) is considered as one of the most promising candidates for pandemic and prepandemic vaccines. LAIV has proven to be safe and efficacious; pandemic LAIV might be more effective than inactivated vaccine in providing broader immune response.


This review covers development of LAIVs against potential avian “pandemic” H5N1 subtype based on cold–adapted A/Leningrad/134/17/57 (H2N2) master donor virus backbone, and their preclinical and clinical studies.

Keywords: Highly pathogenic H5N1 avian influenza, Future pandemic, Live attenuated pandemic influenza vaccine, LAIV, H2N2.