RESEARCH ARTICLE


Iron Acquisition Mechanisms: Promising Target Against Mycobacterium tuberculosis



Saif Hameed#, Rahul Pal#, Zeeshan Fatima*
Amity Institute of Biotechnology, Amity University Haryana, Gurgaon (Manesar)-122413, India


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© Hameed et al.; Licensee Bentham Open.

open-access license: This is an open access article licensed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.

* Address correspondence to this author at the Amity Institute of Biotechnology, Amity University Haryana, Gurgaon (Manesar)-122413, India; Tel: +91-124-2337015, Ext: 1205; E-mail: drzeeshanfatima@gmail.com
# Both authors contributed equally to this work


Abstract

Continuous deployment of antitubercular drugs in treating Tuberculosis (TB) caused by Mycobacterium tuberculosis (MTB) has led to the emergence of drug resistance resulting in cross-resistance to many unrelated drugs, a phenomenon termed as Multi-Drug Resistance (MDR-TB). Despite reasonable documentation of major factors which contribute to MDR mechanisms, it appears unavoidable to consider novel mechanisms combating MDR. The ability of pathogenic MTB, to sense and become accustomed to changes in the host environment is essential for its survival and confers the basis of their success as dreadful pathogen. One such significant environmental factor that MTB must surmount is iron limitation, since they encounter diverse anatomical sites during the establishment of infection within the host. Considering the importance of MTB, being the second most common cause of mortality, this review focuses on gaining insights of iron acquisition mechanisms in MTB and how it can be exploited as efficient anti-mycobacterial drug target.

Keywords: Drug target, iron, multidrug resistance, Mycobacterium tuberculosis.