A Rare Case of Kawasaki-like Multisystem Inflammatory Syndrome following COVID-19 in an Adult

Pepijn Van Hove1, *, Chris Kenyon2, 3
1 Department of Internal Medicine, University Hospital Antwerp (UZA), Antwerp, Belgium
2 HIV/STI Unit, Institute of Tropical Medicine, Antwerp, Belgium
3 Division of Infectious Diseases and HIV Medicine, University of Cape Town, Anzio Road, Observatory7700, Cape Town, South Africa

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© 2021 Van Hove et al.

open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

* Address correspondence to this author at Department of Internal Medicine, University Hospital Antwerp (UZA), Desguinlei 42, 2018 Antwerpen, Belgium; Tel: +32 473 65 25 23; E-mail:


In this case report, we describe a Kawasaki-like multisystem inflammatory syndrome (MIS-A) in a 33-year old man that occurred 19 days after a SARS-CoV-2 infection. The main features at presentation were profound myocarditis, bilateral non-purulent conjunctivitis, mediastinal lymphadenopathy, and acute kidney failure and laboratory evidence of hyperinflammation. He received ACE-inhibition and beta-blockers for his heart failure and made a fairly rapid spontaneous recovery over the subsequent 8 days.

Keywords: Kawasaki-like multisystem inflammatory syndrome (MIS-A), COVID-19, Kawasaki disease, Multisystem inflammatory syndrome, ACE-inhibitors, Mediastinal lymphadenopathy.