REVIEW ARTICLE


Biofilm Targeting Strategy in the Eradication of Burkholderia Infections: A Mini-Review



Wani D. Gunardi1, *
iD
, Kris H. Timotius1
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, Agustine Natasha2
iD
, Paulina R. Evriarti2, 3
iD

1 Department of Microbiology, Faculty of Medicine, Krida Wacana Christian University (UKRIDA), Jakarta, Indonesia
2 Program in Biomedical Science, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia
3 Department of Microbiolgy, Health Labortory of Makassar (BBLK Makassar), Makassar, Indonesia


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Creative Commons License
© 2021 Gunardi et al.

open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: https://creativecommons.org/licenses/by/4.0/legalcode. This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

* Address correspondence to this author at Department of Microbiology, Faculty of Medicine, Krida Wacana Christian University (UKRIDA), Jakarta 11510, Indonesia; E-mail: wani.gunardi@ukrida.ac.id


Abstract

Burkholderia are intracellular pathogenic bacteria which can produce biofilm. This biofilm protects the intracellular pathogenic bacteria from antibiotic treatment and the immunological system of the host. Therefore, this review aims to describe the capacity of Burkholderia to form a biofilm, the regulation of its biofilm formation, the efficacy of antibiotics to eradicate biofilm, and the novel therapy which targets its biofilm. Burkholderia's biofilm is characterized by its lipopolysaccharides, exopolysaccharides (EPSs), biofilm-associated proteins, and eDNA. Its regulation is made by quorum sensing, c-di-AMP, sRNA, and two component systems. Many antibiotics have been used as sole or mixture agents; however, they are not always effective in eradicating the biofilm-forming Burkholderia. Inhibitors of quorum sensing and other non-conventional antibiotic approaches are promising to discover effective treatment of Burkholderia infections.

Keywords: Antibiotic, Biofilm, Burkholderia, Exopolysaccharide, Lipid A, Quorum sensing.