Paracoccidioidomycosis: Current Perspectives from Brazil
Rinaldo Poncio Mendes1, *, Ricardo de Souza Cavalcante1, Sílvio Alencar Marques2, Mariângela Esther Alencar Marques3, James Venturini4, Tatiane Fernanda Sylvestre1, Anamaria Mello Miranda Paniago5, Ana Carla Pereira6, Julhiany de Fátima da Silva1, Alexandre Todorovic Fabro7, Sandra de Moraes Gimenes Bosco8, Eduardo Bagagli8, Rosane Christine Hahn9, Adriele Dandara Levorato1
Identifiers and Pagination:Year: 2017
First Page: 224
Last Page: 282
Publisher Id: TOMICROJ-11-224
Article History:Received Date: 12/07/2017
Revision Received Date: 10/10/2017
Acceptance Date: 10/10/2017
Electronic publication date: 31/10/2017
Collection year: 2017
open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: https://creativecommons.org/licenses/by/4.0/legalcode. This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
This review article summarizes and updates the knowledge on paracoccidioidomycosis. P lutzii and the cryptic species of P. brasiliensis and their geographical distribution in Latin America, explaining the difficulties observed in the serological diagnosis.
Emphasis has been placed on some genetic factors as predisposing condition for paracoccidioidomycosis. Veterinary aspects were focused, showing the wide distribution of infection among animals. The cell-mediated immunity was better characterized, incorporating the recent findings.
Serological methods for diagnosis were also compared for their parameters of accuracy, including the analysis of relapse.
Clinical forms have been better classified in order to include the pictures less frequently observesiod.
Itraconazole and the trimethoprim-sulfamethoxazole combination was compared regarding efficacy, effectiveness and safety, demonstrating that azole should be the first choice in the treatment of paracoccidioidomycosis.