Comparison Between Pathogen Associated Laboratory and Clinical Parameters in Early-Onset Sepsis of the Newborn

Bernhard Resch1, 2, *, Renoldner B1, Hofer N1
1 Research Unit for Neonatal Infectious Diseases and Epidemiology, Medical University of Graz, Graz, Austria
2 Division of Neonatology, Department of Pediatrics, Medical University of Graz, Graz, Austria

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© Resch et al.; Licensee Bentham Open.

open-access license: This is an open access article licensed under the terms of the Creative Commons Attribution-Non-Commercial 4.0 International Public License (CC BY-NC 4.0) (, which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.

* Address correspondence to this author at the Division of Neonatology, Department of Pediatrics Medical University of Graz Auenbruggerplatz 34/2, 8036 Graz, Austria; Tel: ++43 316 385 81134; Fax: ++43 316 385 12678; E-mail:



To identify laboratory and clinical characteristics of different pathogens associated with early-onset sepsis (EOS) of the newborn.


Newborns with EOS were retrospectively analyzed regarding laboratory and clinical parameters associated with the identified pathogen.


We identified 125 newborns having diagnosis of culture proven EOS between 1993 and 2011. One hundred cases had diagnosis of group B streptococci (GBS) infection (80%), 11 had Escherichia coli (8.8%), eight enterococci (6.4%), and six other pathogens (4.8%). White blood cell count (WBC), immature to total neutrophil (IT) ratio, and C-reactive protein (CRP) values did not differ between groups within the first 72 hours of life. Presence of high (>30000/µL) and low (<9000/µl) WBC was significantly less found compared with IT-ratio >0.2 in GBS and E.coli EOS. High WBC were more common found than low WBC in all groups. Gram positive pathogens were more common found in late preterm and term infants (84%), and gram negative pathogens more common in very low birth weight infants (64%). E. coli was significantly associated with lower gestational age and birth weight, respectively.


An abnormal IT-ratio was a more common finding than an abnormal WBC in GBS and E. coli EOS. E. coli was significantly associated with prematurity.

Keywords: Early-onset neonatal sepsis, Escherichia coli, Group B Streptococcus, IT-ratio, White blood cell count.