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Etiology and Epidemiology of Catheter Related Bloodstream Infections in Patients Receiving Home Parenteral Nutrition in a Gastromedical Center at a Tertiary Hospital in Denmark
Xiaohui Chen Nielsen 1 , 2 , *
Ming Chen 2
Anne-Marie Blok Hellesøe 3
Palle Bekker Jeppesen 4
Jonna Gyldenlykke 4
Michael Tvede 2
Leif Percival Andersen 3
Authors Info & Affiliations
Ming Chen 2
Anne-Marie Blok Hellesøe 3
Palle Bekker Jeppesen 4
Jonna Gyldenlykke 4
Michael Tvede 2
Leif Percival Andersen 3
Authors Info & Affiliations
Abstract
We conducted a retrospective epidemiologic study of catheter related bloodstream infections (CRBSI) in patients receiving long-term home parenteral nutrition (HPN) from January 2002 to December 2005. Our results showed that coagulase negative staphylococci (CoNS) were the most prevalent pathogens (44.7% of all CRBSI episodes), followed by Enterobacteriaceae (33.2%). Prevalence for candidemia and Enterococcus bacteremia was relatively high (14.4% and 10.8%, respectively). Cefuroxime resistance was observed in 65.4% CoNS and 31.5% Enterobacteriaceae. Based on the results from the study, a new empiric antimicrobial treatment regiment was suggested.
Keywords: Etiology, epidemiology, intravascular catheter, blood stream infection, home parenteral nutrition, antimicrobial susceptibility.
