Etiology and Epidemiology of Catheter Related Bloodstream Infections in Patients Receiving Home Parenteral Nutrition in a Gastromedical Center at a Tertiary Hospital in Denmark

Xiaohui Chen Nielsen 1, 2, *, Ming Chen 2, Anne-Marie Blok Hellesøe 3, Palle Bekker Jeppesen 4, Jonna Gyldenlykke 4, Michael Tvede 2, Leif Percival Andersen 3
1 Department of Clinical Microbiology, Slagelse Hospital, Slagelse, Denmark
2 Department of Clinical Microbiology, University Hospital of Copenhagen, Denmark
3 Department of Infection Control, University Hospital of Copenhagen, Denmark
4 Department of Gastroenterology, University Hospital of Copenhagen, Copenhagen, Denmark

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© Nielsen et al.; Licensee Bentham Open.

open-access license: This is an open access article licensed under the terms of the Creative Commons Attribution Non-Commercial License ( which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.

* Address correspondence to this author at the Department of Clinical Mi-crobiology, Slagelse Hospital, Region Zealand, Ingemannsvej 18, DK-4200 Slagelse, Denmark; Tel: +45 5855 9404, Fax: +45 5855 9410, E-mail:


We conducted a retrospective epidemiologic study of catheter related bloodstream infections (CRBSI) in patients receiving long-term home parenteral nutrition (HPN) from January 2002 to December 2005. Our results showed that coagulase negative staphylococci (CoNS) were the most prevalent pathogens (44.7% of all CRBSI episodes), followed by Enterobacteriaceae (33.2%). Prevalence for candidemia and Enterococcus bacteremia was relatively high (14.4% and 10.8%, respectively). Cefuroxime resistance was observed in 65.4% CoNS and 31.5% Enterobacteriaceae. Based on the results from the study, a new empiric antimicrobial treatment regiment was suggested.

Keywords: Etiology, epidemiology, intravascular catheter, blood stream infection, home parenteral nutrition, antimicrobial susceptibility.