RESEARCH ARTICLE


Perspectives Concerning Various Symptoms of SARS-CoV-2 Detected Individuals



Tirasak Pasharawipas1, *
1 Faculty of Medical Technology, Rangsit University, Pathumthani, Thailand 12000, Thailand


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Creative Commons License
© 2021 Tirasak Pasharawipas

open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: (https://creativecommons.org/licenses/by/4.0/legalcode). This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

* Address correspondence to this author at the Faculty of Medical Technology, Rangsit University, Pathumthani, Thailand 12000, Thailand; E-mail: tirasak4124@yahoo.com, tirasak.p@rsu.ac.th


Abstract

After exposure to SARS-CoV-2, varying symptoms of COVID-19 ranging from asymptomatic symptoms to morbidity and mortality have been exhibited in each individual. SARS-CoV-2 requires various cellular molecules for penetration into a target host cell. Angiotensin-converting enzyme2 (ACE2) acts as the viral receptor molecule. After attachment, SARS-CoV-2 also requires the transmembrane protease serine-2 (TMPRSS-2) and furin molecules, which serve as co-receptors for penetration into the target cell and for subsequent replication. In the meantime, a major histocompatibility complex (MHC) is required for the induction of adaptive immune cells, especially cytotoxic T cells and helper T cells, to clear the virally infected cells. This perspective review article proposes different aspects to explain the varying symptoms of the individuals who have been exposed to SARS-CoV-2, which relates to the polymorphisms of these involved molecules.

Keywords: SARS-CoV-2, Viral receptor molecules, Polymorphism, Major histocompatibility complex, Viral infection, Viral clearance.