Risk Factors for Acquisition of Fluoroquinolone or Aminoglycoside Resistance in Addition to Carbapenem Resistance in Pseudomonas aeruginosa
Kosuke Kosai1 , *
Norihito Kaku2
Naoki Uno2
Tomomi Saijo3
Yoshitomo Morinaga2
Yoshifumi Imamura3
Hiroo Hasegawa1
Taiga Miyazaki4
Koichi Izumikawa4
Hiroshi Mukae3
Katsunori Yanagihara2
Authors Info & Affiliations
Norihito Kaku2
Naoki Uno2
Tomomi Saijo3
Yoshitomo Morinaga2
Yoshifumi Imamura3
Hiroo Hasegawa1
Taiga Miyazaki4
Koichi Izumikawa4
Hiroshi Mukae3
Katsunori Yanagihara2
Authors Info & Affiliations
Risk Factors for Acquisition of Fluoroquinolone or Aminoglycoside Resistance in Addition to Carbapenem Resistance in Pseudomonas Aeruginosa
The Open Microbiology Journal, 2017, 11-92
The correct Table 2 is mentioned below:
Table 2.
Univariate and multivariate analyses of risk factors for acquisition of fluoroquinolone or aminoglycoside resistance in addition to imipenem resistance in Pseudomonas aeruginosa.
| Univariate analysis | Multivariate analysis | |||||
|---|---|---|---|---|---|---|
| OR | 95%CI | P | OR | 95%CI | P | |
| Resistance to FQs | ||||||
| Transplantation | 1.74 | 0.80-3.78 | 0.161 | |||
| Use of corticosteroids (≥5 mg/day) or other immunosuppressive agents | 1.81 | 0.93-3.52 | 0.082 | |||
| Surgery | 0.65 | 0.35-1.21 | 0.173 | |||
| Exposure to first-generation cephalosporins | 0.60 | 0.30-1.19 | 0.143 | |||
| Exposure to second-generation cephalosporins | 0.28 | 0.08-1.01 | 0.051 | |||
| Exposure to FQs | 5.30 | 2.52-11.14 | <0.001 | 5.73 | 2.67-12.30 | <0.001 |
| Exposure to AGs | 3.92 | 1.30-11.87 | 0.016 | |||
| MBL production | 6.67 | 1.78-24.91 | 0.005 | 7.90 | 2.01-31.04 | 0.003 |
| Resistance to AGs | ||||||
| Use of anticancer drugs | 2.57 | 0.64-10.40 | 0.184 | |||
| Use of urinary catheter | 0.42 | 0.13-1.38 | 0.152 | |||
| Exposure to antipseudomonal penicillins | 0.24 | 0.05-1.14 | 0.073 | 0.16 | 0.03-0.89 | 0.036 |
| Exposure to AGs | 6.04 | 1.59-23.00 | 0.008 | 9.00 | 1.92-42.19 | 0.005 |
| MBL production | 7.35 | 1.89-28.65 | 0.004 | 8.49 | 1.87-38.52 | 0.006 |
OR, odds ratio; CI, confidence interval; FQs, fluoroquinolones; AGs, aminoglycosides; MBL, metallo-β-lactamase
The original table provided was:
Table 2.
Proportion of resistant and MBL-producing strains by presence of FQ or AG resistance in imipenem-resistant Pseudomonas aeruginosa.
| Resistance to FQs | Resistance to AGs | ||||||
|---|---|---|---|---|---|---|---|
|
All strains (n = 169) |
Yes (n = 66) |
No (n = 103) |
P |
Yes (n = 12) |
No (n= 157) |
P | |
| Resistance to antibiotics | |||||||
| Piperacillin1) | 36 (21.3) | 21 (31.8) | 15 (14.6) | 0.003 | 4 (33.3) | 32 (20.4) | 0.347 |
| Ceftazidime1) | 53 (31.4) | 33 (50.0) | 20 (19.4) | <0.001 | 8 (66.7) | 45 (28.7) | 0.022 |
| Cefepim | 38 (22.5) | 28 (42.4) | 10 (9.7) | <0.001 | 7 (58.3) | 31 (19.7) | 0.006 |
| Aztreonam | 91 (53.8) | 45 (68.2) | 46 (44.7) | 0.004 | 9 (75.0) | 82 (52.2) | 0.146 |
| Ciprofloxacin1) | 49 (29.0) | - | - | - | 8 (66.7) | 41 (26.1) | 0.011 |
| Levofloxacin | 60 (35.5) | - | - | - | 6 (50.0) | 54 (34.4) | 0.350 |
| Gentamicin1) | 12 (7.1) | 8 (12.1) | 4 (3.9) | 0.042 | - | - | - |
| Amikacin1) | 4 (2.4) | 3 (4.5) | 1 (1.0) | 0.274 | - | - | - |
| MBL production | 14 (8.3) | 11 (16.7) | 3 (2.9) | 0.003 | 4 (33.3) | 10 (6.4) | 0.010 |
Values are expressed as the number (%).
FQs, fluoroquinolones; AGs, aminoglycosides; MBL, metallo-β-lactamase 1)Minimum inhibitory concentrations (MICs) for piperacillin, ceftazidime, ciprofloxacin, gentamicin and amikacin were not measured in eleven, one, one, one, and thirteen strains, respectively.
FQs, fluoroquinolones; AGs, aminoglycosides; MBL, metallo-β-lactamase 1)Minimum inhibitory concentrations (MICs) for piperacillin, ceftazidime, ciprofloxacin, gentamicin and amikacin were not measured in eleven, one, one, one, and thirteen strains, respectively.
