Understanding the Mechanism of Bacterial Biofilms Resistance to Antimicrobial Agents
Shriti Singh1, Santosh Kumar Singh2, Indrajit Chowdhury3, Rajesh Singh2, *
Identifiers and Pagination:Year: 2017
First Page: 53
Last Page: 62
Publisher ID: TOMICROJ-11-53
Article History:Received Date: 10/10/2016
Revision Received Date: 15/02/2017
Acceptance Date: 15/02/2017
Electronic publication date: 28/04/2017
Collection year: 2017
open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: https://creativecommons.org/licenses/by/4.0/legalcode. This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
A biofilm is a group of microorganisms, that causes health problems for the patients with indwelling medical devices via attachment of cells to the surface matrix. It increases the resistance of a microorganism for antimicrobial agents and developed the human infection. Current strategies are removed or prevent the microbial colonies from the medical devices, which are attached to the surfaces. This will improve the clinical outcomes in favor of the patients suffering from serious infectious diseases. Moreover, the identification and inhibition of genes, which have the major role in biofilm formation, could be the effective approach for health care systems. In a current review article, we are highlighting the biofilm matrix and molecular mechanism of antimicrobial resistance in bacterial biofilms.