Understanding the Mechanism of Bacterial Biofilms Resistance to Antimicrobial Agents



Shriti Singh1, Santosh Kumar Singh2, Indrajit Chowdhury3, Rajesh Singh2, *
1 Department of Kriya Sharir, Institute of Medical Sciences, Banaras Hindu University, Varanasi- 221 005 UP India
2 Department of Microbiology, Biochemistry and Immunology, Morehouse School of Medicine, Atlanta, GA, USA
3 Department of Obstetrics and Gynecology; Morehouse School of Medicine, Atlanta, GA, USA


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© 2017 Singh et al.

open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: https://creativecommons.org/licenses/by/4.0/legalcode. This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

* Address correspondence to this author at the Department of Microbiology, Biochemistry and Immunology, Morehouse School of Medicine 720 Westview Drive SW, Atlanta, GA 30310, USA; Tel: 404-756-6661; Fax: 404-752-1179; E-mail: rsingh@msm.edu


Abstract

A biofilm is a group of microorganisms, that causes health problems for the patients with indwelling medical devices via attachment of cells to the surface matrix. It increases the resistance of a microorganism for antimicrobial agents and developed the human infection. Current strategies are removed or prevent the microbial colonies from the medical devices, which are attached to the surfaces. This will improve the clinical outcomes in favor of the patients suffering from serious infectious diseases. Moreover, the identification and inhibition of genes, which have the major role in biofilm formation, could be the effective approach for health care systems. In a current review article, we are highlighting the biofilm matrix and molecular mechanism of antimicrobial resistance in bacterial biofilms.

Keywords: Biofilm, Quorum sensing, Efflux pump, Heterogeneity, Resistance.